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KMID : 0376219780150010041
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Chonnam Medical Journal
1978 Volume.15 No. 1 p.41 ~ p.47
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Parasympathetic Vasodilatation in the Submaxillary Gland of the Cat
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Abstract
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Heidenhain earlier reported that a small dose of atropine completely blocked the secretion produced by stimulation of the chorda tympani, but the concomitant intense vasodilatation was practically unaffected. Since then, it has long been arguing whether the chorda tympani contains specific vasodilator fibers. The existence of vasodilator fibers in the chorda tympani was challenged by discovery of kallikrein, a potent vasodilator substance, which was released into venous effluents following the stimulation of the nerve. Kallikrein has been thought to be the mediator of functional vasodilatation not only in the salivary glands, but also in sweat, pancreatic and other glands by some workers. On the other hand, Skinner et al. have shown that stimulation of the chorda tympani increases the submaxillary blood flow even after the administration of carboxypeptidase B, a rapid, potent inactivator of kinins.
The present experiments were undertaken to establish evidences as to the existence of specific vasodilator fibers in the chorda tympani and to elucidate their nature. The results obtained were as follows.
1. Stimulation of the chorda tympani produced salivary secretion and increased the blood flow through the submaxillary gland.
2. Submaxillary secretion by the chorda, stimulation was completely blocked after the intravenous administration of atropine or scopolamine, but increased blood flow was unaffected by either drug.
3. Nfter atropinization, intraarterial injection of acetylcholine, physostigmine or pilocarpine increased the submaxillary blood flow.
4. Increased submaxillary blood flow by the chorda stimulation was augmented by simultaneous intraarterial injection of. physostigmine.
5. These results suggest that increased submaxillary blood-flow by the chorda stimulation is due to specific vasodilator fibers contained in the chorda tympani, which seems to be, atropine-resistant cholinergic in nature.
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